Hyperinflammation and Fibrosis in Severe COVID-19 Patients: Galectin-3, a Target Molecule to Consider

Glycovirology

There is a strong rationale to use plasma galectin-3 as a prognostic biomarker in COVID-19 and theorizes that inhibiting galectin-3 is a feasible therapeutic approach. Galectin-3 drives inflammation in immune responses, fibrosis, and hypoxia which are part of the COVID-19 pathology. Since there are tolerable Galectin-3 inhibitors clinical trials are feasible. Galectin-3 is also a prognostic biomarker for severe COVID-19.

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